Effect of salt content on the photoacoustic detection of glucose solutions

Zhong Ren; Guodong Liu

doi:10.1117/12.2531149

17 May 2019 Effect of salt content on the photoacoustic detection of glucose solutions

Zhong Ren, Guodong Liu

Proceedings Volume 11170, 14th National Conference on Laser Technology and Optoelectronics (LTO 2019); 1117003 (2019) https://doi.org/10.1117/12.2531149
Event: Fourteenth National Conference on Laser Technology and Optoelectronics, 2019, Shanghai, China

Abstract

In this paper, the effect of salt content on the photoacoustic detection and the concentration prediction of glucose was experimentally investigated. The photoacoustic detection system of glucose based on optical parameters oscillator (OPO) pulsed laser and the non-focused ultrasonic transducer in the lateral model was established. The test phantom aqueous solutions combined different salt contents and the different concentrations of glucose were prepared. The test solutions were divided into two types according to the different salt contents, i.e., the lower salt contents (100-500mg/dl) and the higher salt contents (1-4g/dl). Based on the established experimental system, the time-resolved photoacoustic signals and peak-to-peak values of test solutions with different salt contents and different glucose concentrations were all obtained. The linear fitting models for each salt content were established to predict the glucose concentration. Experimental results show that, with the increase of the salt content and glucose concentration, the photoacoustic amplitude increases with the salt content and glucose concentration. The root-mean-square error (RMSE) values of the predicted glucose for the test solutions with lower salt contents are less than that of the higher salt contents. The RMSE value of glucose concentration for the test solutions with the salt content of 100mg/dl is about 13.61mg/dl, its correction coefficient reaches 0.99211. For the test solutions with the salt content of 3g/dl, the RMSE value of glucose concentration is about 62.36mg/dl, its correction coefficient is about 0.85294. Therefore, the influences of higher salt contents on the photoacoustic detection and glucose concentration prediction are more serious than that of the lower salt contents.

Citation Download Citation

Zhong Ren and Guodong Liu "Effect of salt content on the photoacoustic detection of glucose solutions", Proc. SPIE 11170, 14th National Conference on Laser Technology and Optoelectronics (LTO 2019), 1117003 (17 May 2019); https://doi.org/10.1117/12.2531149

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KEYWORDS

Glucose

Photoacoustic spectroscopy

Ultrasonics

Blood

Pulsed laser operation

Transducers

Optical parametric oscillators

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