Laser-induced focused ultrasound for noninvasive sonothrombolysis using candle soot polymer nanocomposite-coated photoacoustic lens

Guangxin Ding; Hui Xia

doi:10.1117/12.2533587

17 May 2019 Laser-induced focused ultrasound for noninvasive sonothrombolysis using candle soot polymer nanocomposite-coated photoacoustic lens

Guangxin Ding, Hui Xia

Author Affiliations +

Proceedings Volume 11170, 14th National Conference on Laser Technology and Optoelectronics (LTO 2019); 1117023 (2019) https://doi.org/10.1117/12.2533587
Event: Fourteenth National Conference on Laser Technology and Optoelectronics, 2019, Shanghai, China

Abstract

In this paper, a concave carbon-based polymer nanocomposite film was developed for high-amplitude focused ultrasound. The composite films consisting of candle soot nanoparticles (CSNPs) and elastomeric polymers were used as the high-frequency optoacoustic sources. To generated focused ultrasound, these composite films were formed on concave optical lens. A focal waveform with peak to peak pressure of ~45 MPa was achieved at the focal point. The prototyped laser-induced focused ultrasound (LIFU) was applied with noninvasive sonothrombolysis in vitro. For enhanced cavitation effect, we demonstrated a spatio-temporal superposition approach of LIFU treatment in conjunction with low-frequency focused ultrasound from a piezoelectric ultrasound transducer. The in vitro results showed that dualfrequency excitation ultrasound treatment can achieve the sonothrombolysis efficiency of approximately 28% in half of an hour (2 mg/min), suggesting that LIFU generated from composite films may be promising in precision sonothrombolysis.

Citation Download Citation

Guangxin Ding and Hui Xia "Laser-induced focused ultrasound for noninvasive sonothrombolysis using candle soot polymer nanocomposite-coated photoacoustic lens", Proc. SPIE 11170, 14th National Conference on Laser Technology and Optoelectronics (LTO 2019), 1117023 (17 May 2019); https://doi.org/10.1117/12.2533587

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KEYWORDS

Ultrasonography

Transducers

Cavitation

Laser energy

Photoacoustic spectroscopy

Ferroelectric materials

In vitro testing

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