Confocal video microscopy reveals altered leukocyte-endothelial interactions in skin preceding acute graft-versus-host disease (Conference Presentation)

Inga Saknite; Michael Byrne; Madan Jagasia; Eric R. Tkaczyk

doi:10.1117/12.2543808

6 March 2020 Confocal video microscopy reveals altered leukocyte-endothelial interactions in skin preceding acute graft-versus-host disease (Conference Presentation)

Inga Saknite, Michael Byrne, Madan Jagasia, Eric R. Tkaczyk

Author Affiliations +

Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 112110G (2020) https://doi.org/10.1117/12.2543808
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Through noninvasive monitoring of leukocyte motion in skin capillaries of patients after hematopoietic cell transplantation, we found increased leukocyte rolling and adhesion prior to clinical signs of disease. In this longitudinal pilot study, we explored the feasibility to detect changes in leukocyte-endothelial interactions that precede acute graft-versus-host disease in patients after hematopoietic cell transplantation. We present the pattern of change in leukocyte rolling and adhesion in three patients over the course of the first 100 days post-transplant. Our preliminary data show increased leukocyte-endothelial interactions prior to clinical signs of any organ acute graft-versus-host disease.

Conference Presentation

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Inga Saknite, Michael Byrne, Madan Jagasia, and Eric R. Tkaczyk "Confocal video microscopy reveals altered leukocyte-endothelial interactions in skin preceding acute graft-versus-host disease (Conference Presentation)", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110G (6 March 2020); https://doi.org/10.1117/12.2543808

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KEYWORDS

Skin

Confocal microscopy

Video microscopy

Microscopes

Transplantation

Video

Capillaries

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