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6 March 2020 Full resolution PS-OCT assessment of airway smooth muscle in a longitudinal bronchial thermoplasty study (Conference Presentation)
David C. Adams, Jasmin A. Holz, Andrew F. McCrossan, Lida P. Hariri, Margit V. Szabari, Melissa J. Suter
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Proceedings Volume 11214, Endoscopic Microscopy XV; 112140C (2020) https://doi.org/10.1117/12.2545139
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
The goal of bronchial thermoplasty (BT) is to reduce the symptoms associated with asthma by ablating the hyper-responsive airway smooth (ASM), but results have been mixed. In this work we present the results of a study in which we imaged canines before and after BT using polarization-sensitive optical coherence tomography (PS-OCT) in order to assess the potential of PS-OCT for use in conjunction with the BT procedure. By employing a novel processing technique we demonstrate PS-OCT results obtained at full system resolution, allowing us to accurately measure even vanishingly thin ASM distributions following the BT procedure.
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David C. Adams, Jasmin A. Holz, Andrew F. McCrossan, Lida P. Hariri, Margit V. Szabari, and Melissa J. Suter "Full resolution PS-OCT assessment of airway smooth muscle in a longitudinal bronchial thermoplasty study (Conference Presentation)", Proc. SPIE 11214, Endoscopic Microscopy XV, 112140C (6 March 2020); https://doi.org/10.1117/12.2545139
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KEYWORDS
Clinical trials
Optical coherence tomography
Optical resolution
Polarization
Therapeutics
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