Optical properties of human gums after photodynamic therapy with methylene blue (in vitro)

A. A. Selifonov; T. M. Zagorovskaya; O. V. Syrova; O. Yu. Aleshkina; D. A. Zimnyakov; V. V. Tuchin

doi:10.1117/12.2547577

19 February 2020 Optical properties of human gums after photodynamic therapy with methylene blue (in vitro)

A. A. Selifonov, T. M. Zagorovskaya, O. V. Syrova, O. Yu. Aleshkina, D. A. Zimnyakov, V. V. Tuchin

Proceedings Volume 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020; 1122315 (2020) https://doi.org/10.1117/12.2547577
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

The work is devoted to determining the diffusion coefficient of methylene blue in human gum tissue in vitro using spectroscopic methods. The calculations are based on the application of the free diffusion model, the second Fick law, and the modified Bouguer – Lambert – Beer law. For the first time, the diffusion coefficient of methylene blue into the tissue of the human gingival mucosa in vitro was determined, which, by averaging 10 samples is (1.26±0.34)·10^–7cm²/s. It was revealed that after the gum is completely stained with dye, the light does not pass into the biological tissue from 200-699 nm, which includes the areas of dye absorption peaks necessary for photoactivation of the dye during photodynamic therapy. The results obtained are important for the personified choice of this method in vivo in the treatment of superficial pathological localizations.

Citation Download Citation

A. A. Selifonov, T. M. Zagorovskaya, O. V. Syrova, O. Yu. Aleshkina, D. A. Zimnyakov, and V. V. Tuchin "Optical properties of human gums after photodynamic therapy with methylene blue (in vitro)", Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 1122315 (19 February 2020); https://doi.org/10.1117/12.2547577

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available