Optical coherence angiography reveals changes in murine fetal brain vasculature due to maternal exposure to nicotine

Raksha Raghunathan; Chih-Hao Liu; Amur Kouka; Yogeshwari Ambekar; Connie Yan; Noemi Bustamante; Manmohan Singh; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2554020

21 February 2020 Optical coherence angiography reveals changes in murine fetal brain vasculature due to maternal exposure to nicotine

Raksha Raghunathan, Chih-Hao Liu, Amur Kouka, Yogeshwari Ambekar, Connie Yan, Noemi Bustamante, Manmohan Singh, Rajesh C. Miranda, Kirill V. Larin

Author Affiliations +

Proceedings Volume 11239, Dynamics and Fluctuations in Biomedical Photonics XVII; 112390D (2020) https://doi.org/10.1117/12.2554020
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In the United States, 20% of pregnant women are estimated to smoke, thus affecting 800,000 babies annually. Maternal nicotine exposure is known to have several detrimental effects on the developing fetus including intrauterine growth restriction, perinatal mortality and morbidity, placental abruption, and other childhood disorders. In humans, studies evaluating the association between maternal cigarette smoking during pregnancy and behavioral development in offsprings have shown negative influences of nicotine on brain development. Although several studies have documented lower birth weights, morphological and behavioral changes, not much has been done evaluating the acute changes in brain vasculature after prenatal exposure to nicotine. This work uses correlation mapping optical coherence angiography (cm-OCA), a functional extension of optical coherence tomography, to evaluate changes in murine fetal brain vasculature, in utero, minutes after maternal nicotine exposure. A rapid and significant decrease in vasculature was observed compared to the sham group.

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Raksha Raghunathan, Chih-Hao Liu, Amur Kouka, Yogeshwari Ambekar, Connie Yan, Noemi Bustamante, Manmohan Singh, Rajesh C. Miranda, and Kirill V. Larin "Optical coherence angiography reveals changes in murine fetal brain vasculature due to maternal exposure to nicotine", Proc. SPIE 11239, Dynamics and Fluctuations in Biomedical Photonics XVII, 112390D (21 February 2020); https://doi.org/10.1117/12.2554020

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