Towards in vivo PA imaging of vulnerable plaques in carotid arteries (Conference Presentation)

Min Wu; Elcke Vloedgraven; Roy van Hees; Jan-Willem Muller; Marc Van Sambeek; Frans van de Vosse; Richard Lopata; Hans-Martin Schwab

doi:10.1117/12.2541946

20 April 2020 Towards in vivo PA imaging of vulnerable plaques in carotid arteries (Conference Presentation)

Min Wu, Elcke Vloedgraven, Roy van Hees, Jan-Willem Muller, Marc Van Sambeek, Frans van de Vosse, Richard Lopata, Hans-Martin Schwab

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124005 (2020) https://doi.org/10.1117/12.2541946
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Rupture of carotid plaques triggers stroke. Current diagnosis of stroke is based on lumen stenosis, resulting in sever overtreatment. Photoacoustic (PA) imaging can provide comprehensive and patient-specific assessment of plaque vulnerability, and prevent overtreatment. However, no in vivo PA imaging of carotid plaque is available due to low SNR. Here, we present a fast PA/US imaging system and motion corrected averaging algorithm to increase PA SNR. The imaging system and algorithm are verified ex vivo, and in vivo on patients during carotid endarterectomy (intra-operatively). The results may accelerate the clinical translation of PA imaging of carotid plaques.

Conference Presentation

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Min Wu, Elcke Vloedgraven, Roy van Hees, Jan-Willem Muller, Marc Van Sambeek, Frans van de Vosse, Richard Lopata, and Hans-Martin Schwab "Towards in vivo PA imaging of vulnerable plaques in carotid arteries (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124005 (20 April 2020); https://doi.org/10.1117/12.2541946

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KEYWORDS

In vivo imaging

Arteries

Signal to noise ratio

Imaging systems

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