Photoacoustic microscopy by spatial overlap modulation using femtosecond optical pulse train (Conference Presentation)

Yoshihisa Yamaoka; Koki Matsumoto; Yusuke Notsuka; Eiji Takahashi

doi:10.1117/12.2545607

6 March 2020 Photoacoustic microscopy by spatial overlap modulation using femtosecond optical pulse train (Conference Presentation)

Yoshihisa Yamaoka, Koki Matsumoto, Yusuke Notsuka, Eiji Takahashi

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124022 (2020) https://doi.org/10.1117/12.2545607
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Two-photon photoacoustic microscopy (TP-PAM) can visualize deep structures in living tissues with high spatial resolution determined by the volume of nonlinear absorption. Generally, the out-of-focus background fluorescence limits the imaging depth in nonlinear optical microscopies. In this study, to overcome this drawback that is also expected to exist in TP-PAM, we propose TP-PAM with spatial overlap modulation using femtosecond optical pulse train. Because the modulation depth of the spatial overlap in the focal region is much greater than those in out-of-focus regions, the out-of-focus background is effectively rejected by extracting the modulated photoacoustic signals.

Conference Presentation

Citation Download Citation

Yoshihisa Yamaoka, Koki Matsumoto, Yusuke Notsuka, and Eiji Takahashi "Photoacoustic microscopy by spatial overlap modulation using femtosecond optical pulse train (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124022 (6 March 2020); https://doi.org/10.1117/12.2545607

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available