Towards quantitative photoacoustic tomography for partial view array transducers

Eghbal Amidi; Guang Yang; K. M. Shihab Uddin; Hongbo Luo; Stephen Rogers; Allan Doctor; Quing Zhu

doi:10.1117/12.2547143

17 February 2020 Towards quantitative photoacoustic tomography for partial view array transducers

Eghbal Amidi, Guang Yang, K. M. Shihab Uddin, Hongbo Luo, Stephen Rogers, Allan Doctor, Quing Zhu

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112404G (2020) https://doi.org/10.1117/12.2547143
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

One of the challenges of quantitative Photoacoustic (PA) imaging is unmixing the optical absorption (μa) of the tissue from system response (C) and Grüneisen parameter (Γ). In this study, we have calculated the absorption coefficient and functional parameters, i.e. total hemoglobin (tHb) and oxygen saturation (sO2) of 5 blood tubes with sO2 values ranging from 24.9% to 97.6% at different depths in intralipid solution. Beer’s law is used to calculate the optical fluence in the target area. Initial values for μ_a and C×Γ are found by fitting a line to the log of PA beam data. These initial values are iteratively updated using a conjugate gradient method. This process is repeated for all 11 wavelengths. The absorption coefficient spectrum follows the molar extinction coefficient spectrum of deoxy hemoglobin for lower sO2 percentages, and it becomes closer to the spectrum of oxy hemoglobin when the sO2 percentage increases. The calculated absorption coefficients at 11 wavelengths are used to estimate the absolute value of the tHb and sO2 of each blood sample at different depths. The mean error of the estimated tHb values for blood tubes at all depths with respect to the real values are less than 13%. Moreover, the largest sO2 estimation error is 7.5% for the blood sample with sO2 of 24.9%. Our quantitative PA method performed well for the data collected from blood samples. We are investigating this method on our clinical data.

Citation Download Citation

Eghbal Amidi, Guang Yang, K. M. Shihab Uddin, Hongbo Luo, Stephen Rogers, Allan Doctor, and Quing Zhu "Towards quantitative photoacoustic tomography for partial view array transducers", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112404G (17 February 2020); https://doi.org/10.1117/12.2547143

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KEYWORDS

Blood

Absorption

Tissues

Tissue optics

Acquisition tracking and pointing

Photoacoustic tomography

Transducers

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