Simple, rapid and cost-effective drug-susceptibility testing of leukemia by intelligent whole-blood imaging flow cytometry (Conference Presentation)

Hirofumi Kobayashi; Cheng Lei; Yi Wu; Chun-Jung Huamg; Atsushi Yasumoto; Masahiro Jona; Wenxuan Li; Yaxiaer Yalikun; Baoshan Guo; Chia-Wei Sun; Yo Tanaka; Makoto Yamada; Yutaka Yatomi; Keisuke Goda

doi:10.1117/12.2545017

10 March 2020 Simple, rapid and cost-effective drug-susceptibility testing of leukemia by intelligent whole-blood imaging flow cytometry (Conference Presentation)

Hirofumi Kobayashi, Cheng Lei, Yi Wu, Chun-Jung Huamg, Atsushi Yasumoto, Masahiro Jona, Wenxuan Li, Yaxiaer Yalikun, Baoshan Guo, Chia-Wei Sun, Yo Tanaka, Makoto Yamada, Yutaka Yatomi, Keisuke Goda

Author Affiliations +

Proceedings Volume 11250, High-Speed Biomedical Imaging and Spectroscopy V; 112500Y (2020) https://doi.org/10.1117/12.2545017
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We present an extreme-throughput (>1 million cells per second) imaging flow cytometer with deep learning to achieve a highly simple, rapid, and cost-effective liquid biopsy for ex-vivo drug-susceptibility testing of leukemia. The drug resistance of leukemia cells was detected in whole blood with only 24-hour drug treatment without hemolysis or dilution, making the sample preparation extremely simple, rapid and cost-effective. Our method also accurately evaluated the drug susceptibility of white blood cells from untreated patients with acute lymphoblastic leukemia, holding great promise for affordable precision medicine.

Conference Presentation

Citation Download Citation

Hirofumi Kobayashi, Cheng Lei, Yi Wu, Chun-Jung Huamg, Atsushi Yasumoto, Masahiro Jona, Wenxuan Li, Yaxiaer Yalikun, Baoshan Guo, Chia-Wei Sun, Yo Tanaka, Makoto Yamada, Yutaka Yatomi, and Keisuke Goda "Simple, rapid and cost-effective drug-susceptibility testing of leukemia by intelligent whole-blood imaging flow cytometry (Conference Presentation)", Proc. SPIE 11250, High-Speed Biomedical Imaging and Spectroscopy V, 112500Y (10 March 2020); https://doi.org/10.1117/12.2545017

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available