Label free optical cell and tissue characterization for veterinary pathology and teratology (Conference Presentation)

Jürgen Schnekenburger; Alvaro Barroso Pena; Björn Kemper

doi:10.1117/12.2546737

10 March 2020 Label free optical cell and tissue characterization for veterinary pathology and teratology (Conference Presentation)

Jürgen Schnekenburger, Alvaro Barroso Pena, Björn Kemper

Author Affiliations +

Proceedings Volume 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020; 112510K (2020) https://doi.org/10.1117/12.2546737
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

The pathological examination of regulatory relevant tissue samples is done manually and highly time consuming. Label free optical technologies like quantitative phase microscopy (QPM) and Optical Coherence Tomography (OCT) provide fast analysis of fixated cells and tissues by biophysical parameters. Combination of various wavelengths allows label free QPM tissue characterization equivalent to HE staining. Recent OCT studies showed 3D imaging of rat embryo details as bone structures, full vertebra, whole feet and parts of the skull. The multi-functional potential of QPM and OCT represents a promising new approach for label free phenotyping of regulatory relevant cell and tissue alterations.

Conference Presentation

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Jürgen Schnekenburger, Alvaro Barroso Pena, and Björn Kemper "Label free optical cell and tissue characterization for veterinary pathology and teratology (Conference Presentation)", Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS) 2020, 112510K (10 March 2020); https://doi.org/10.1117/12.2546737

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KEYWORDS

Tissue optics

Tissues

Optical coherence tomography

Chemical analysis

Pathology

Statistical analysis

Microscopy

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