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10 March 2020 Highly sensitive and reliable plasmonic nanoparticle-based digital cytometry for quantification of MUC16 binding on the surface of leukocytes (Conference Presentation)
Sinyoung Jeong, Germán González, Nicholas Nowell, Lauren A. Austin, Jawad Hoballah, Fatima Mubarak, Arvinder Kapur, Manish S. Patankar, Daniel W. Cramer, Petra Krauledat, W. Peter Hansen, Conor L. Evans
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Proceedings Volume 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII; 112540R (2020) https://doi.org/10.1117/12.2545088
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
We recently developed a digital cytometric assay using plasmonic nanoparticles to quantify the bound ovarian cancer marker (CA125) on single cells. We demonstrate the quantification capability of our novel digital cytometry method by discriminating the different MUC16 binding levels on the PBMCs between healthy donors and EOC patients. Furthermore, we tracked the amount of surface-bound MUC16 on the EOC patient’s PBMCs over 17 months with 1-month time intervals. Initial data from our cytometric technique shows it to be a quantitative tool that can provide new information connecting leukocyte-bound MUC16 to the time course of ovarian cancer.
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Sinyoung Jeong, Germán González, Nicholas Nowell, Lauren A. Austin, Jawad Hoballah, Fatima Mubarak, Arvinder Kapur, Manish S. Patankar, Daniel W. Cramer, Petra Krauledat, W. Peter Hansen, and Conor L. Evans "Highly sensitive and reliable plasmonic nanoparticle-based digital cytometry for quantification of MUC16 binding on the surface of leukocytes (Conference Presentation)", Proc. SPIE 11254, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII, 112540R (10 March 2020); https://doi.org/10.1117/12.2545088
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KEYWORDS
Plasmonics
Ovarian cancer
Gold
Nanoparticles
Blood
Cancer
Molecules
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