Prospects for using laser fluorescence spectroscopy and optical oximetry for an objective assessment of the minimal erythema dose

Mikhail Makmatov-Rys; Alexey Glazkov; Irina Raznitsyna; Dmitry Kulikov; Anton Molochkov; Ekaterina Kaznacheeva; Dmitry Rogatkin

doi:10.1117/12.2559468

9 April 2020 Prospects for using laser fluorescence spectroscopy and optical oximetry for an objective assessment of the minimal erythema dose

Mikhail Makmatov-Rys, Alexey Glazkov, Irina Raznitsyna, Dmitry Kulikov, Anton Molochkov, Ekaterina Kaznacheeva, Dmitry Rogatkin

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Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570A (2020) https://doi.org/10.1117/12.2559468
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

Minimal erythema dose (MED) is the amount of ultraviolet (UV) radiation needed to induce a mild skin erythema reaction after 24 hours following exposure. Determination of MED is based on the assessment of UV-erythema and traditionally performed visually by naked eye, which is subjective and connected with errors due to high intrarater and interrater variability. The application of non-invasive and quantitative techniques such as optical methods could improve MED calculation, allowing us to detect and quantify alterations in epidermis and dermis induced by UV irradiation. In the current study the analysis of microcirculation parameters by non-invasive optical methods revealed the relationship between the oxygen consumption and a dose of UV radiation. Results also showed the correlation of oxygen consumption of UV-exposed tissues normalized to intact skin with a dose of UV. Moreover, we described tendencies in dynamics of porphyrin fluorescence intensity at different time points after UV-exposure. Optical methods have some prospects in non-invasive and predictive evaluation of UV erythema and MED and more research should be conducted in this field.

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Mikhail Makmatov-Rys, Alexey Glazkov, Irina Raznitsyna, Dmitry Kulikov, Anton Molochkov, Ekaterina Kaznacheeva, and Dmitry Rogatkin "Prospects for using laser fluorescence spectroscopy and optical oximetry for an objective assessment of the minimal erythema dose", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570A (9 April 2020); https://doi.org/10.1117/12.2559468

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KEYWORDS

Skin

Ultraviolet radiation

Luminescence

Tissue optics

Tissues

Abdomen

UV optics

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