The study of spectral changes in THz range in normal and pathological skin in vivo depending on the dehydration methods used

Irina Yu. Yanina; Viktor V. Nikolaev; Alexey V. Borisov; Anastasia I. Knyazkova; Evgeniy E. Buyko; Vyacheslav I. Kochubey; Vladimir V. Ivanov; Yury V. Kistenev; Valery V. Tuchin

doi:10.1117/12.2563192

9 April 2020 The study of spectral changes in THz range in normal and pathological skin in vivo depending on the dehydration methods used

Irina Yu. Yanina, Viktor V. Nikolaev, Alexey V. Borisov, Anastasia I. Knyazkova, Evgeniy E. Buyko, Vyacheslav I. Kochubey, Vladimir V. Ivanov, Yury V. Kistenev, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570Q (2020) https://doi.org/10.1117/12.2563192
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

The terahertz (THz) attenuated total reflectance (ATR) imaging of normal and pathological skin under the action of various dehydration agents was carried out in vivo. Studies were conducted on animal models (the mouse), patients with diabetes, and healthy volunteers. For measurements, each animal was leaned against the ATR prism of the skin surface, and several locations in the skin of each animal were analyzed. Places on the skin for analysis were chosen so that the intensity spectra of the THz signal were practically the same for selected points. THz spectra measurements were carried out every 10 minutes within 45 minutes interval under the action of a dehydration agent. 40% glucose was shown to provide the most effective improving tissue optical clearing effect in the THz range.

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Irina Yu. Yanina, Viktor V. Nikolaev, Alexey V. Borisov, Anastasia I. Knyazkova, Evgeniy E. Buyko, Vyacheslav I. Kochubey, Vladimir V. Ivanov, Yury V. Kistenev, and Valery V. Tuchin "The study of spectral changes in THz range in normal and pathological skin in vivo depending on the dehydration methods used", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570Q (9 April 2020); https://doi.org/10.1117/12.2563192

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KEYWORDS

Skin

Terahertz radiation

Absorption

Glucose

In vivo imaging

Blood

Medical research

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