Super-resolution imaging enabled by metamaterial-assisted speckle illumination nanoscopy

Junxiang Zhao; Yeon Ui Lee; Qian Ma; Larousse Khosravi Khorashad; Clara Posner; Guangru Li; Zachary Burns; Jin Zhang; Zhaowei Liu

doi:10.1117/12.2568829

20 August 2020 Super-resolution imaging enabled by metamaterial-assisted speckle illumination nanoscopy

Junxiang Zhao, Yeon Ui Lee, Qian Ma, Larousse Khosravi Khorashad, Clara Posner, Guangru Li, Zachary Burns, Jin Zhang, Zhaowei Liu

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Proceedings Volume 11468, Enhanced Spectroscopies and Nanoimaging 2020; 114681C (2020) https://doi.org/10.1117/12.2568829
Event: SPIE Nanoscience + Engineering, 2020, Online Only

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Abstract

Structured illumination microscope (SIM) enables high temporal resolution wide field-of-view super-resolution imaging but typically provides only two-fold resolution improvement over the diffraction limit. We report speckle metamaterial-assisted illumination nanoscopy (Speckle-MAIN) which brings the resolution down to 40nm and beyond. A hyperbolic metamaterial structure is implemented as substrate to generate deep sub-wavelength speckle-like illumination pattern at the near field of the metamaterial. Fluorescent objects are illuminated by such high spatial-frequency near field illuminations and are reconstructed by a Blind-SIM algorithm. Speckle-MAIN provides a new route for low-cost easy-implemented super-resolution imaging with ultra-high resolution and biocompatibility.

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Junxiang Zhao, Yeon Ui Lee, Qian Ma, Larousse Khosravi Khorashad, Clara Posner, Guangru Li, Zachary Burns, Jin Zhang, and Zhaowei Liu "Super-resolution imaging enabled by metamaterial-assisted speckle illumination nanoscopy", Proc. SPIE 11468, Enhanced Spectroscopies and Nanoimaging 2020, 114681C (20 August 2020); https://doi.org/10.1117/12.2568829

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