Intelligent, high speed, high resolution, and tomographic phase microscopy

Renjie Zhou

doi:10.1117/12.2573227

15 June 2020 Intelligent, high speed, high resolution, and tomographic phase microscopy

Renjie Zhou

Proceedings Volume 11521, Biomedical Imaging and Sensing Conference 2020; 115210C (2020) https://doi.org/10.1117/12.2573227
Event: SPIE Technologies and Applications of Structured Light, 2020, Yokohama, Japan

Abstract

Quantitative phase microscopy (QPM) has been widely applied to many biological imaging and material metrology applications. Our lab has recently empowered QPM with artificial intelligence (AI), ultrahigh imaging speed, and 3D imaging capability. In one study we have built an artificial neural network for white blood cell (WBC) classification by using thousands of labeled WBC phase images from over 5 healthy human subjects. This ANN has been able to successfully predict the WBC counts of new human subjects with 90% accuracy on average. In the second study, we have implemented high speed digital micro-mirror devices (DMDs) and high-speed image sensor to achieve synthetic aperture phase imaging and 3D imaging of transparent thin material structures with ~200 nm resolution at <500 fps speed, which can be used for cytometry and histopathology applications.

Citation Download Citation

Renjie Zhou "Intelligent, high speed, high resolution, and tomographic phase microscopy", Proc. SPIE 11521, Biomedical Imaging and Sensing Conference 2020, 115210C (15 June 2020); https://doi.org/10.1117/12.2573227

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