Removing skin microvessels using photo‐mediated ultrasound therapy (PUT)

Mingyang Wang; Yu Qin; Tao Wang; Jeffrey Orringer; Yannis Paulus M.D.; Xinmai Yang; Xueding Wang

doi:10.1117/12.2576379

5 March 2021 Removing skin microvessels using photo‐mediated ultrasound therapy (PUT)

Mingyang Wang, Yu Qin, Tao Wang, Jeffrey Orringer, Yannis Paulus M.D., Xinmai Yang, Xueding Wang

Proceedings Volume 11618, Photonics in Dermatology and Plastic Surgery 2021; 1161805 (2021) https://doi.org/10.1117/12.2576379
Event: SPIE BiOS, 2021, Online Only

Abstract

We have developed a novel anti-vascular technique, termed photo-mediated ultrasound therapy (PUT), which utilizes nanosecond duration laser pulses synchronized with ultrasound bursts to remove microvasculature through cavitation. In this work, via the experiments in a rabbit ear model in vivo, the feasibility of PUT in the treatment of cutaneous microvessels was explored. Both the short-term effects and the long-term effects up to 4 weeks post-treatment were quantitatively assessed by measuring the perfusion rates of the vessels after treatment, showing that a single PUT treatment could significantly reduce blood perfusion. With unique advantages such as low laser fluence as compared with photothermolysis and agent-free treatment as compared with PDT, PUT holds potential to be developed into a new tool for the treatment of cutaneous vascular lesions.

Conference Presentation

Citation Download Citation

Mingyang Wang, Yu Qin, Tao Wang, Jeffrey Orringer, Yannis Paulus M.D., Xinmai Yang, and Xueding Wang "Removing skin microvessels using photo‐mediated ultrasound therapy (PUT)", Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 1161805 (5 March 2021); https://doi.org/10.1117/12.2576379

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