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5 March 2021 Integrated simultaneous multimodality photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for rabbit ocular imaging in vivo and safety evaluation
Wei Zhang, Yanxiu Li, Van Phuc Nguyen, Yannis M. Paulus M.D., Xueding Wang
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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116230O (2021) https://doi.org/10.1117/12.2576600
Event: SPIE BiOS, 2021, Online Only
Abstract
A simultaneous multimodality imaging system combining photoacoustic microscopy (PAM), optical coherence tomography (OCT), and fluorescence microscopy (FM) was developed, and its performance and safety for ocular imaging was validated on rabbit eye in vivo. Angiogenesis and bleeding can be selectively shown by label free PAM with laser fluence at only 1% of the ANSI safety limit. OCT imaging allows for visualization of the different retinal layers with high axial resolution. The leakage of neovascularization can be verified with FM. The safety of PAM was evaluated by comprehensive longitudinal follow-up with ocular imaging methods, electrophysiology, histology, immunohistochemistry, and electron microscopy.
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Wei Zhang, Yanxiu Li, Van Phuc Nguyen, Yannis M. Paulus M.D., and Xueding Wang "Integrated simultaneous multimodality photoacoustic microscopy, optical coherence tomography, and fluorescence microscopy for rabbit ocular imaging in vivo and safety evaluation", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230O (5 March 2021); https://doi.org/10.1117/12.2576600
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KEYWORDS
In vivo imaging
Optical coherence tomography
Safety
Luminescence
Microscopy
Photoacoustic microscopy
Fermium
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