Ygal Rotenstreich M.D.https://orcid.org/0000-0003-2366-1779,1 Adi Tzameret,1 Zehavit Goldberg,1 Ettel Bubis,1 Noa Avni-Zauberman M.D.,1 Ofra Kalter-Leibovici,2 Arie L. Marcovich M.D.,3 Guy Ben Simon M.D.,1 Ifat Sher1
1The Chaim Sheba Medical Ctr., Tel Hashomer (Israel) 2The Gertner Institute (Israel) 3Kaplan Medical Ctr. (Israel)
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In this preclinical study we demonstrated that treatment with repetitive magnetic stimulation (RMS) protects the epithelial layer in a rabbit model of exposure keratopathy, preventing loss of the epithelial cells and maintaining the function of the corneal barrier under extreme desiccation conditions. A single 15 minutes RMS treatment supported corneal barrier integrity under acute desiccation for 3 months. AS-OCT imaging and histopathology analysis demonstrated the safety of RMS treatment. Our study suggests that repetitive magnetic stimulation may present a novel treatment for protection of corneal epithelium in patients with DES, and may alleviate DES symptoms.
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Ygal Rotenstreich M.D., Adi Tzameret, Zehavit Goldberg, Ettel Bubis, Noa Avni-Zauberman M.D., Ofra Kalter-Leibovici, Arie L. Marcovich M.D., Guy Ben Simon M.D., Ifat Sher, "Protection of corneal epithelium by repetitive magnetic stimulation in a rabbit model of dry eye," Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116230Q (5 March 2021); https://doi.org/10.1117/12.2583382