Photo-mediated ultrasound therapy for treatment of corneal neovascularization in rabbit eyes

Yu Qin; Yixin Yu; Julia Fu; Xinyi Xie; Tao Wang; Yannis M. Paulus M.D.; Xinmai Yang; Xueding Wang

doi:10.1117/12.2576595

5 March 2021 Photo-mediated ultrasound therapy for treatment of corneal neovascularization in rabbit eyes

Yu Qin, Yixin Yu, Julia Fu, Xinyi Xie, Tao Wang, Yannis M. Paulus M.D., Xinmai Yang, Xueding Wang

Proceedings Volume 11623, Ophthalmic Technologies XXXI; 116231V (2021) https://doi.org/10.1117/12.2576595
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

Photo-mediated ultrasound therapy (PUT) holds potential as a novel antivascular method. In this work, we applied PUT to precisely remove corneal neovascularization in a rabbit eye model. A stable corneal suture-induced corneal neovascularization model was established in rabbits. These rabbits were later treated by PUT or used as controls. The treatment outcomes were evaluated through red-free photography and fluorescein angiography along with histology and immunohistochemistry. The experimental results demonstrated that PUT shows promise in improving the management of eye diseases by delivering selective treatment to pathologic vessels with minimized side effects.

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Citation Download Citation

Yu Qin, Yixin Yu, Julia Fu, Xinyi Xie, Tao Wang, Yannis M. Paulus M.D., Xinmai Yang, and Xueding Wang "Photo-mediated ultrasound therapy for treatment of corneal neovascularization in rabbit eyes", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 116231V (5 March 2021); https://doi.org/10.1117/12.2576595

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