CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11625 > Article
Presentation
5 March 2021 Pharmacology of near infrared nerve-specific fluorophores for fluorescence-guided nerve sparing surgical procedures
Connor W. Barth, Lei Wang, Antonio Montaño, Alexander Antaris, Jonathan Sorger, Summer Gibbs
Author Affiliations +
Proceedings Volume 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII; 116250R (2021) https://doi.org/10.1117/12.2583265
Event: SPIE BiOS, 2021, Online Only
Abstract
Nerve damage plagues surgical outcomes, significantly affecting post-surgical quality of life. Intraoperative nerve detection is difficult since neuroanatomy is varilable between patients, and nerves are typically protected deep within the tissue. Fluorescence-guided surgery (FGS) offers a potential means for enhanced intraoperative nerve identification and preservation. We have developed the first near infrared (NIR) nerve-specific fluorophores for use during FGS. Lead optimization has yielded water soluble derivatives with excellent safety and pharmacology parameters. Work is underway to plan and execute preclinical toxicity testing to enable first-in-human clincial trials.
Conference Presentation
© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Connor W. Barth, Lei Wang, Antonio Montaño, Alexander Antaris, Jonathan Sorger, and Summer Gibbs "Pharmacology of near infrared nerve-specific fluorophores for fluorescence-guided nerve sparing surgical procedures", Proc. SPIE 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII, 116250R (5 March 2021); https://doi.org/10.1117/12.2583265
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Nerve
Near infrared
Pharmacology
Animal model studies
Safety
Toxicity
Visualization
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top