MHV-1 in vivo viral load reduction via antibody-conjugated photodynamic inactivation

Jace A. Willis; Vsevolod Cheburkanov; Giulia Kassab; Vanderlei S. Bagnato; Vladislav V. Yakovlev

doi:10.1117/12.2577893

5 March 2021 MHV-1 in vivo viral load reduction via antibody-conjugated photodynamic inactivation

Jace A. Willis, Vsevolod Cheburkanov, Giulia Kassab, Vanderlei S. Bagnato, Vladislav V. Yakovlev

Proceedings Volume 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021; 116260C (2021) https://doi.org/10.1117/12.2577893
Event: SPIE BiOS, 2021, Online Only

Abstract

Photodynamic inactivation (PDI) has been widely applied to localized infections, both internal and external. However, there is a notable knowledge gap when it comes to applying PDI to an entire organ system or even systemically throughout an organism. To study these treatment methods, an in vivo murine model of MHV-1 is planned. As a respiratory coronavirus, the model provides a suitable system for study, in addition to potential determination of systemic results. Specifically applied, MHV-1 has many key characteristics, such as symptoms and viral protein structures, that are in common or similar to other coronaviruses. Thus, this theorized model simultaneously addresses a key knowledge gap and provides useful insights into potential treatments for COVID-19 and similar disease-causing viruses. The risk of emergent viral threats and the necessity for rapidly developed, adaptable, affordable treatment methods are both now vividly evident.

Conference Presentation

Citation Download Citation

Jace A. Willis, Vsevolod Cheburkanov, Giulia Kassab, Vanderlei S. Bagnato, and Vladislav V. Yakovlev "MHV-1 in vivo viral load reduction via antibody-conjugated photodynamic inactivation", Proc. SPIE 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021, 116260C (5 March 2021); https://doi.org/10.1117/12.2577893

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