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5 March 2021 Photoacoustic stimulation with single neuron precision
Linli Shi, Ying Jiang, Ji-Xin Cheng, Chen Yang
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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116290P (2021) https://doi.org/10.1117/12.2578734
Event: SPIE BiOS, 2021, Online Only
Abstract
Towards non-genetic, precise neural stimulation, we develop a photoacoustic neural stimulation technology. It employs a fiber-based optoacoustic process, in which pulsed light is delivered through an optical fiber into an absorbing layer coated at the tip, resulting in transient heating and generating a localized acoustic wave. We report photoacoustic stimulation in vitro and in vivo through a lab-built fiber based optoacoustic emitter (FOE). Single neuron optoacoustic neural modulation is achieved through a tapered FOE (TFOE) developed with negligible thermal deposition. TFOE single neuron stimulation is shown to be compatible with patch and provides insights towards mechanical modulation of neural systems.
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Linli Shi, Ying Jiang, Ji-Xin Cheng, and Chen Yang "Photoacoustic stimulation with single neuron precision", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116290P (5 March 2021); https://doi.org/10.1117/12.2578734
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KEYWORDS
Neurons
Photoacoustic spectroscopy
Optoacoustics
In vitro testing
Magnetic resonance imaging
Optical fibers
Optogenetics
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