Real-time measurements of pO2 gradients, CBF, and CMRO2 in the rat brain during functional activation

Sang Hoon Chong; Yi Hong Ong; Mirna El Khatib; Srinivasa Rao Allu; Ashwin B. Parthasarathy; Joel H. Greenberg; Arjun G. Yodh; Sergei A. Vinogradov

doi:10.1117/12.2579418

5 March 2021 Real-time measurements of pO2 gradients, CBF, and CMRO2 in the rat brain during functional activation

Sang Hoon Chong, Yi Hong Ong, Mirna El Khatib, Srinivasa Rao Allu, Ashwin B. Parthasarathy, Joel H. Greenberg, Arjun G. Yodh, Sergei A. Vinogradov

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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291Z (2021) https://doi.org/10.1117/12.2579418
Event: SPIE BiOS, 2021, Online Only

Abstract

We present a novel method for real-time measurement of the oxygen (pO2) gradients between intra- and extra-vascular compartments in rat brain cortex during functional activation. This information, obtained in parallel with measurements of cerebral blood flow (CBF), permits determination of absolute cerebral metabolic rate of oxygen (CMRO2). The timing of pO2, CBF, and CMRO2 responses is captured with high temporal resolution (~7 Hz). We discuss these results in the context of physiological models that connect oxidative metabolism to neuronal activation.

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Sang Hoon Chong, Yi Hong Ong, Mirna El Khatib, Srinivasa Rao Allu, Ashwin B. Parthasarathy, Joel H. Greenberg, Arjun G. Yodh, and Sergei A. Vinogradov "Real-time measurements of pO2 gradients, CBF, and CMRO2 in the rat brain during functional activation", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291Z (5 March 2021); https://doi.org/10.1117/12.2579418

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KEYWORDS

Brain

Oxygen

Near infrared spectroscopy

Positron emission tomography

Mode conditioning cables

Neuroimaging

Neurovascular coupling

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