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5 March 2021 Bidirectional interface for real-time optoacoustic monitoring of transcranial ultrasound stimulation in rodents
Ali Özbek, Justine Robin, Héctor Andrés Estrada Beltrán, Shy Shoham, Daniel Razanksy
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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116292C (2021) https://doi.org/10.1117/12.2577846
Event: SPIE BiOS, 2021, Online Only
Abstract
Despite the growing use of transcranial focused ultrasound (TUS) methods in pre-clinical research, noninvasive real-time monitoring of the TUS procedures remains an open challenge. Here we devised a wide-angle spherical array bidirectional interface for high-resolution parallelized optoacoustic imaging and transcranial ultrasound delivery (POTUS). The system is capable of generating and steering tightly focused ultrasound spots across a field of view covering the entire mouse brain, while the same array is used to capture 3D optoacoustic data in real time. We showcase the system’s versatile beam-forming capacities as well as volumetric optoacoustic imaging capabilities.
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Ali Özbek, Justine Robin, Héctor Andrés Estrada Beltrán, Shy Shoham, and Daniel Razanksy "Bidirectional interface for real-time optoacoustic monitoring of transcranial ultrasound stimulation in rodents", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116292C (5 March 2021); https://doi.org/10.1117/12.2577846
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KEYWORDS
Ultrasonography
Optoacoustics
Brain
Neuroimaging
Imaging systems
Skull
Spatial resolution
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