Closed loop wavefront sensing and correction in mouse brain enabled by computed optical coherence microscopy

Siyang Liu; Fei Xia; Xusan Yang; Meiqi Wu; Laurie A. Bizimana; Chris Xu; Steven G. Adie

doi:10.1117/12.2583924

5 March 2021 Closed loop wavefront sensing and correction in mouse brain enabled by computed optical coherence microscopy

Siyang Liu, Fei Xia, Xusan Yang, Meiqi Wu, Laurie A. Bizimana, Chris Xu, Steven G. Adie

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 1163007 (2021) https://doi.org/10.1117/12.2583924
Event: SPIE BiOS, 2021, Online Only

Abstract

Optical coherence microscopy (OCM) captures the optical field with high sensitivity and thus enables computational wavefront retrieval. Compared to a real-time wavefront sensor, wavefront measurement with OCM in post-processing uses coherence and confocal gate to obtain signals with less spatial crosstalk. Also, since this approach only requires a single shot, it is more robust to in vivo sample motion than sensorless adaptive optics. By computational aberration sensing and hardware correction, we demonstrated a physical compensation of the intentionally induced aberration at the white matter layer (~900 μm) in an ex vivo mouse brain.

Conference Presentation

Citation Download Citation

Siyang Liu, Fei Xia, Xusan Yang, Meiqi Wu, Laurie A. Bizimana, Chris Xu, and Steven G. Adie "Closed loop wavefront sensing and correction in mouse brain enabled by computed optical coherence microscopy", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 1163007 (5 March 2021); https://doi.org/10.1117/12.2583924

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