Scanning interferometric Near-Infrared Spectroscopy (iNIRS): towards time-of-flight resolved imaging of human brain blood flow

Oybek Kholiqov; Wenjun Zhou; Soroush GhandiParsi; Vivek J. Srinivasan

doi:10.1117/12.2583652

5 March 2021 Scanning interferometric Near-Infrared Spectroscopy (iNIRS): towards time-of-flight resolved imaging of human brain blood flow

Oybek Kholiqov, Wenjun Zhou, Soroush GhandiParsi, Vivek J. Srinivasan

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 1163009 (2021) https://doi.org/10.1117/12.2583652
Event: SPIE BiOS, 2021, Online Only

Abstract

Interferometric Near-Infrared Spectroscopy (iNIRS) is a time-of-flight- (TOF-) resolved method to measure diffuse optical field dynamics from the human brain. Here we demonstrate a non-contact, null source-collector separation iNIRS approach based on polarization splitting, which enables galvanometer-based scanning across large spatial fields-of-view and suppresses single and few-scattered superficial light that degrades the effective dynamic range for deep measurements. We present, for the first time, multi-dimensional TOF- and laterally-resolved data sets that describe human forehead dynamics. The resulting blood flow index images show significant spatial heterogeneity in superficial dynamics, helping to identify optimal regions for subsequent monitoring with improved brain specificity.

Conference Presentation

Citation Download Citation

Oybek Kholiqov, Wenjun Zhou, Soroush GhandiParsi, and Vivek J. Srinivasan "Scanning interferometric Near-Infrared Spectroscopy (iNIRS): towards time-of-flight resolved imaging of human brain blood flow", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 1163009 (5 March 2021); https://doi.org/10.1117/12.2583652

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Brain

Blood circulation

Interferometry

Near infrared spectroscopy

Neuroimaging

Light

Tissue optics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years