Non-invasive detection and characterization of Otitis Media with Raman spectroscopy

Sean Fitzgerald; Andrea Locke; Anita Mahadevan-Jansen; Oscar Ayala

doi:10.1117/12.2577252

5 March 2021 Non-invasive detection and characterization of Otitis Media with Raman spectroscopy

Sean Fitzgerald, Andrea Locke, Anita Mahadevan-Jansen, Oscar Ayala

Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 1163106 (2021) https://doi.org/10.1117/12.2577252
Event: SPIE BiOS, 2021, Online Only

Abstract

Otitis media (OM) is a group of inflammatory diseases of the middle ear and is the most frequent cause of physician visits and antibiotic prescriptions for children. Current diagnostic methods do not differentiate acute otitis media from otitis media with effusion, as both types of OM share many symptomatic features. A cohort of around 50 patients undergoing myringotomy were enrolled in this study, where Raman spectroscopy (RS) allowed non-invasive determination of OM subtype. Here we demonstrate the potential for RS to probe OM infection status in pediatric patients, to guide treatment protocol for ear infections and limit over-prescription of antibiotics.

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Sean Fitzgerald, Andrea Locke, Anita Mahadevan-Jansen, and Oscar Ayala "Non-invasive detection and characterization of Otitis Media with Raman spectroscopy", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 1163106 (5 March 2021); https://doi.org/10.1117/12.2577252

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KEYWORDS

Raman spectroscopy

Ear

Bragg cells

Remote sensing

Tissue optics

Diagnostics

In vivo imaging

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