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We developed refined methods for time-domain measurements of the optical properties of solid homogeneous turbid phantoms. Employing a reliable time-domain reference setup with a stable, narrow, and clean instrument response function and GPU-based Monte-Carlo fitting, 1% accuracy for optical properties seems realistic. An alternative space-enhanced time-domain method that combines spatially resolved amplitude with a time-domain measurement effectively reduced the crosstalk between absorption and scattering. Besides physical phantoms, we explored and characterized a digital phantom that mimics arbitrary time-of-flight distributions via time-dependent attenuation employing a spatial light modulator and a dedicated multi-fiber delay unit. We discuss potential applications in performance tests.
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Heidrun Wabnitz, Lin Yang, Thomas Gladytz, Lina Hacker, James Joseph, Dirk Grosenick, "Accurate characterization of phantoms for performance assessment and calibration in diffuse optics," Proc. SPIE 11633, Design and Quality for Biomedical Technologies XIV, 1163306 (5 March 2021); https://doi.org/10.1117/12.2588994