Characterization of tissue-mimicking phantoms for evaluating photoacoustic microscopy image quality

Hsun-Chia Hsu; Joshua Pfefer; William C. Vogt

doi:10.1117/12.2578782

5 March 2021 Characterization of tissue-mimicking phantoms for evaluating photoacoustic microscopy image quality

Hsun-Chia Hsu, Joshua Pfefer, William C. Vogt

Proceedings Volume 11633, Design and Quality for Biomedical Technologies XIV; 1163308 (2021) https://doi.org/10.1117/12.2578782
Event: SPIE BiOS, 2021, Online Only

Abstract

Photoacoustic imaging (PAI) and photoacoustic microscopy (PAM) continue to undergo advancement, but standardized performance test methods are needed to facilitate development and translation. Most tissue-mimicking materials (TMMs) have not been adequately characterized at high acoustic frequencies relevant to PAM systems (>20 MHz). We characterized acoustic properties of various polyacrylamide TMM formulations over 10-60 MHz using a pulse-echo method, while optical properties were characterized over 400-1000 nm. We evaluated performance of a custom PAM system using phantoms containing gold nanoparticles. Polyacrylamide had highly tunable acoustic properties similar to human skin, and performance tests provided key insights into PAM system performance.

Conference Presentation

Citation Download Citation

Hsun-Chia Hsu, Joshua Pfefer, and William C. Vogt "Characterization of tissue-mimicking phantoms for evaluating photoacoustic microscopy image quality", Proc. SPIE 11633, Design and Quality for Biomedical Technologies XIV, 1163308 (5 March 2021); https://doi.org/10.1117/12.2578782

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