Development and validation of the theory of Interferometric dynamic laser speckle imaging

Sharvari Zilpelwar; Xiaojun Cheng; David A. Boas

doi:10.1117/12.2577780

5 March 2021 Development and validation of the theory of Interferometric dynamic laser speckle imaging

Sharvari Zilpelwar, Xiaojun Cheng, David A. Boas

Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 116410K (2021) https://doi.org/10.1117/12.2577780
Event: SPIE BiOS, 2021, Online Only

Abstract

Dynamic laser speckle imaging (DLSI) is an optical technique that directly measures the temporal speckle intensity fluctuations with sufficient temporal sampling to correctly model and predict the underlying blood flow changes. The speckle measurements are limited to superficial tissues and it lacks three-dimensional imaging of blood flow. To perform depth-resolved measurement, we developed Interferometric Dynamic Laser Speckle Imaging (iDLSI) capable of three-dimensional volumetric measurements of the dynamics. Here, we present the analytical expression for g²,iDLSI(τ) dependent on particle dynamics, coherence properties, sample, and reference intensity. The numerical validations are performed in a homogeneous and in spatially varying dynamic regions.

Conference Presentation

Citation Download Citation

Sharvari Zilpelwar, Xiaojun Cheng, and David A. Boas "Development and validation of the theory of Interferometric dynamic laser speckle imaging", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410K (5 March 2021); https://doi.org/10.1117/12.2577780

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