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Development of a noninvasive glucose meter is of great importance for hundreds of millions of diabetics to dramatically improve their lifestyle and quality of life. We have successfully developed an ultrasound-modulated optical sensing system, consisting of an infrared laser and a single-element ultrasound transducer, for noninvasive glucose measurement. Using focused ultrasound as an optical modulator, strong optical absorption contrast at high spatial resolution could be achieved in a scattering medium. Modulation efficiency was improved by 2.5 times using ultrasound bursts. Further, the proposed system successfully measured glucose concentration in a tissue-mimicking phantom with 26.6% accuracy.
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Eunyeong Park, Jinwoo Baik, Hyojin Kim, Sung-Min Park, Chulhong Kim, "Non-invasive glucose measurement with ultrasound-modulated optical sensing," Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420I (5 March 2021); https://doi.org/10.1117/12.2576875