Characterizing the aggressiveness of prostate cancer using an all optical photoacoustic needle probe: feasibility study

Linyu Ni; Javed Siddiqui; Aaron Udager; Xueding Wang; Guan Xu

doi:10.1117/12.2577211

5 March 2021 Characterizing the aggressiveness of prostate cancer using an all optical photoacoustic needle probe: feasibility study

Linyu Ni, Javed Siddiqui, Aaron Udager, Xueding Wang, Guan Xu

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116420W (2021) https://doi.org/10.1117/12.2577211
Event: SPIE BiOS, 2021, Online Only

Abstract

This study examines the performance of an all-optical and disposable photoacoustic needle probe for characterizing the aggressiveness of prostate cancer in human samples ex vivo. The needle probe consists of a 800um diameter fiber diffuser and a 200um diameter fiber optics hydrophone. The signals acquired by the needle probes were quantified by photoacoustic spectral analysis and envelop statistic methods. Both methods have differentiated between normal tissues and cancerous tissues (n=30 p<0.005), as well as between indolent and aggressiveness cancer tissues (n=16, p<0.01) with statistical significance.

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Citation Download Citation

Linyu Ni, Javed Siddiqui, Aaron Udager, Xueding Wang, and Guan Xu "Characterizing the aggressiveness of prostate cancer using an all optical photoacoustic needle probe: feasibility study", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420W (5 March 2021); https://doi.org/10.1117/12.2577211

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