Wavelength optimization in spectroscopic photoacoustic for the characterization of vulnerable carotid plaques

Camilo Antonio Cano Barrera; Min Wu; Marc R. H. M. van Sambeek; Richard G. P. Lopata

doi:10.1117/12.2578395

5 March 2021 Wavelength optimization in spectroscopic photoacoustic for the characterization of vulnerable carotid plaques

Camilo Antonio Cano Barrera, Min Wu, Marc R. H. M. van Sambeek, Richard G. P. Lopata

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116420X (2021) https://doi.org/10.1117/12.2578395
Event: SPIE BiOS, 2021, Online Only

Abstract

Assessment of morphology and composition of plaques is paramount to characterize their vulnerability. Spectroscopic photoacoustic imaging (sPAI) can image different components, but unmixing accuracy is subject to a proper wavelength selection. In this study, we analyzed the spectral response of plaque tissue in a broad spectral range and proposed a new wavelength selection method based on endmember determination. The method was validated in human plaque samples and phantoms. Results show that our method improves spectral unmixing, and it is possible to characterize plaque composition using at least as many wavelengths as constituents of interest.

Conference Presentation

Citation Download Citation

Camilo Antonio Cano Barrera, Min Wu, Marc R. H. M. van Sambeek, and Richard G. P. Lopata "Wavelength optimization in spectroscopic photoacoustic for the characterization of vulnerable carotid plaques", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420X (5 March 2021); https://doi.org/10.1117/12.2578395

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