Ultrahigh sensitive optical coherence elastography

Yan Li; Sucbei Moon; Jason Chen; Zhikai Zhu; Zhongping Chen

doi:10.1117/12.2576433

5 March 2021 Ultrahigh sensitive optical coherence elastography

Yan Li, Sucbei Moon, Jason Chen, Zhikai Zhu, Zhongping Chen

Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 116450I (2021) https://doi.org/10.1117/12.2576433
Event: SPIE BiOS, 2021, Online Only

Abstract

Phase stability of an optical coherence elastography (OCE) system is the key determining factor for precision elasticity measurement. In this study, we developed an OCE system based on swept-source optical coherence tomography (SS-OCT) with a common-path configuration (SS-OCECP). Our system has a phase stability of 4.2 mrad without external stabilization or extensive post-processing, such as averaging. This phase stability allows us to detect a displacement as small as ~300 pm. We validated the SS-OCECP performance in a tissue-mimicking phantom and an in vivo rabbit model, and the results demonstrated significant improved phase stability compared to conventional SS-OCE. To the best of our knowledge, we demonstrated the first SS-OCECP system, which possess high phase stability and can be utilized to significantly improve the sensitivity of elastography.

Conference Presentation

Citation Download Citation

Yan Li, Sucbei Moon, Jason Chen, Zhikai Zhu, and Zhongping Chen "Ultrahigh sensitive optical coherence elastography", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 116450I (5 March 2021); https://doi.org/10.1117/12.2576433

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available