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5 March 2021 Optofluidic microstructured fibers: a base for measuring the Brownian motion of diffusing nano objects
Markus A. Schmidt, Torsten Wieduwilt, Malte Plidschun, Mona Nissen, Shiqi Jiang, Ronny Förster
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Proceedings Volume 11690, Smart Photonic and Optoelectronic Integrated Circuits XXIII; 116900C (2021) https://doi.org/10.1117/12.2579715
Event: SPIE OPTO, 2021, Online Only
Abstract
High-speed tracking of nano-objects is a gateway to understanding biological processes at the nanoscale. Here we will present our results on tracking single or ensembles of nano-objects inside optofluidic fibers via elastic light scattering. The nano-objects diffuse inside a channel of a microstructured fiber and the light scattered by the nano-object is detected transversely via a microscope. We will present the fundamentals of this approach and focus on selected results including retrieval of the full 3D trajectory of a diffusing nano-sphere, the simultaneous detection of hundreds of nano-objects in hollow core anti-resonant fibers and first results on inactivated SARS-CoV-2.
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Markus A. Schmidt, Torsten Wieduwilt, Malte Plidschun, Mona Nissen, Shiqi Jiang, and Ronny Förster "Optofluidic microstructured fibers: a base for measuring the Brownian motion of diffusing nano objects", Proc. SPIE 11690, Smart Photonic and Optoelectronic Integrated Circuits XXIII, 116900C (5 March 2021); https://doi.org/10.1117/12.2579715
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KEYWORDS
Optical fibers
Optofluidics
Motion measurement
Light scattering
Structured optical fibers
Polymer optical fibers
Polymers
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