A Fiberoptic Antibody-Based Biosensor With Time-Resolved Detection

T. Vo-Dinh; T. Nolan; Y. F. Cheng; J. P. Alarie; M. J. Sepaniak

doi:10.1117/12.963196

13 February 1990 A Fiberoptic Antibody-Based Biosensor With Time-Resolved Detection

T. Vo-Dinh, T. Nolan, Y. F. Cheng, J. P. Alarie, M. J. Sepaniak

Proceedings Volume 1172, Chemical, Biochemical, and Environmental Fiber Sensors; (1990) https://doi.org/10.1117/12.963196
Event: OE/FIBERS '89, 1989, Boston, United States

Abstract

A phase-resolved fiberoptic antibody-based biosensor is desci ibed, which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiberoptic sensors, and the selectivity of phase-resolved detection. The device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. The limit of detection of benzo(a)pyrene tetrol is in the attomole range (10^-18moles).

Citation Download Citation

T. Vo-Dinh, T. Nolan, Y. F. Cheng, J. P. Alarie, and M. J. Sepaniak "A Fiberoptic Antibody-Based Biosensor With Time-Resolved Detection", Proc. SPIE 1172, Chemical, Biochemical, and Environmental Fiber Sensors, (13 February 1990); https://doi.org/10.1117/12.963196

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