Visible-light optical coherence tomography: new anatomical and functional imaging capabilities in tissue imaging

Hao F. Zhang

doi:10.1117/12.2596964

21 June 2021 Visible-light optical coherence tomography: new anatomical and functional imaging capabilities in tissue imaging

Hao F. Zhang

Author Affiliations +

Proceedings Volume 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V; 1178611 (2021) https://doi.org/10.1117/12.2596964
Event: SPIE Optical Metrology, 2021, Online Only

Abstract

While traditional optical coherence tomography (OCT) uses near-infrared light, visible-light OCT or vis-OCT takes advantage of the much higher tissue contrast within visible light spectral range to extract physiological and pathological information in addition to ultra-high (1.3 µm) resolution anatomical imaging. Using vis-OCT, for example, we detected retinal ischemia well before the onset of angiogenesis in diabetic mouse models; produced the first three-dimensional imaging of the entire Schlemm’s canal and limbal vascular network noninvasively; and detected ganglion cell damage when clinical biomarkers were normal in glaucoma mouse models. Working with collaborators, we are also aggressively developing human vis-OCT systems and clinical protocols to improve clinical management of diabetic retinopathy and glaucoma.

Conference Presentation

Citation Download Citation

Hao F. Zhang "Visible-light optical coherence tomography: new anatomical and functional imaging capabilities in tissue imaging", Proc. SPIE 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, 1178611 (21 June 2021); https://doi.org/10.1117/12.2596964

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available