Tissue-like phantoms mimicking blood vessel for intravascular optical coherence tomography

A. Yu. Potlov; S. G. Proskurin; S. V. Frolov

doi:10.1117/12.2590620

4 May 2021 Tissue-like phantoms mimicking blood vessel for intravascular optical coherence tomography

A. Yu. Potlov, S. G. Proskurin, S. V. Frolov

Proceedings Volume 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine; 118450P (2021) https://doi.org/10.1117/12.2590620
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

A method for cerebral vessel tissue-like phantom making and a device for the realizing pulsating flows in them are described. The blood vessels are molded together with models of the organs carrying them. A blood vessel phantom is a hollow structure with three-layered walls mimicking its geometry, structure, inhomogeneity of optical and mechanical properties. The model of an organ serves only for fixing the hollow structure of it in anatomically correct position and therefore is homogeneous in texture and properties. The source of information about the geometry of the imitated blood vessel is the results of angiography of a real clinical case. The three-layered structure of phantoms is justified by the anatomical features of real blood vessels (outer layer - adventitia, middle layer - media, inner layer - intima). The three-layered structure is made by layer-by-layer application of a transparent two-component liquid silicone on a wax base. Each layer is distinguished by its thickness and unique concentration of special admixtures (titanium dioxide nanoparticles and absorbing colorant). Mechanical properties of the layers are changed by varying the concentration of the components of the transparent liquid silicone. The phantom is solidified and then heated to remove the wax. Then the phantom of a blood vessel is placed in a mold of a corresponding organ. The mimicking organ is also made from a two-component transparent liquid silicone with special admixtures. Both proximal and distal ends of the hollow structure are connected with fork catheters. A 1% of intralipid solution in water is used to simulate blood flow in the phantom. Streaming velocity control of a blood-mimicking liquid is provided by a syringe pump. Pulsating flow is generated by the controlled twisting of the tube between the pump and the phantom of a blood vessel. A vibration motor is used to change the velocity profile. The described experimental model of a hydrodynamic phantom of a blood vessel is used in combination with intravascular optical coherence tomography for checking compression elastography properties.

Citation Download Citation

A. Yu. Potlov, S. G. Proskurin, and S. V. Frolov "Tissue-like phantoms mimicking blood vessel for intravascular optical coherence tomography", Proc. SPIE 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine, 118450P (4 May 2021); https://doi.org/10.1117/12.2590620

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