Comparison of different light sources for hemoporfin mediated photodynamic activity

Na Meng; Sen Wang; Shuling Zou; Min Li; Min Wang; Zheng Huang

doi:10.1117/12.2600765

9 October 2021 Comparison of different light sources for hemoporfin mediated photodynamic activity

Na Meng, Sen Wang, Shuling Zou, Min Li, Min Wang, Zheng Huang

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119000Z (2021) https://doi.org/10.1117/12.2600765
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Abstract

Hemporfin is asecond generation photosensitizerand has been used in combination with laser and LED to treat vascular and cancerousdiseases in China. In this study, four different light sources were evaluated for Hemoporfin PDT. Photobleaching experiments were carried out by exposing Hemoporfin solution to green diode laser, red diode laser, green LED, and red LED, respectively, under the same power density (30 mW/cm²) for different lengths of time. Hemoporfin fluorescence was measured before and after light exposure. Photobleaching kinetics showed the order of greenlaser > green LED > red laser> red LED. This study suggests that all tested light sources could be used for Hemoporfin PDTbut the power density and exposure time of different light sources need to be adjusted in order to achieve the same levels of photodynamic effect.

Conference Presentation

Citation Download Citation

Na Meng, Sen Wang, Shuling Zou, Min Li, Min Wang, and Zheng Huang "Comparison of different light sources for hemoporfin mediated photodynamic activity", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119000Z (9 October 2021); https://doi.org/10.1117/12.2600765

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