A spectral-domain model-based method for simultaneous oxygen saturation quantification and contrast agent identification

Hongzhi Zuo; Manxiu Cui; Bangyan Wang; Cheng Ma

doi:10.1117/12.2602598

9 October 2021 A spectral-domain model-based method for simultaneous oxygen saturation quantification and contrast agent identification

Hongzhi Zuo, Manxiu Cui, Bangyan Wang, Cheng Ma

Author Affiliations +

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 1190036 (2021) https://doi.org/10.1117/12.2602598
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

Unmixing multispectral photoacoustic (PA) images is difficult because the excitation spectra in deep tissue are contaminated by absorption and scattering of the surrounding tissue in a highly unpredictable manner. In this work, we found a close relationship between the covariance matrix of a multispectral photoacoustic image and its average tissue oxygenation level. Based on the photon diffusion process, a spectral-domain model of multispectral photoacoustic imaging is established. Combined with the above two findings, accurate estimation of blood oxygen saturation (median error 2.7%) and accurate probe identification (detection rate 86%, false alarm rate 0.035%) were realized in realistic simulation test.

Citation Download Citation

Hongzhi Zuo, Manxiu Cui, Bangyan Wang, and Cheng Ma "A spectral-domain model-based method for simultaneous oxygen saturation quantification and contrast agent identification", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 1190036 (9 October 2021); https://doi.org/10.1117/12.2602598

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available