Raman spectroscopy experimental spectrum analysis for identification in Mycobacterium tuberculosis strains with diﬀerent drug resistance

Andrey Zyubin; Anastasia Lavrova; Eugenie Postnikov; Marine Dogonadze; Elizaveta Demishkevich; Anna Kundalevich; Ilia Samusev

doi:10.1117/12.2602528

9 October 2021 Raman spectroscopy experimental spectrum analysis for identification in Mycobacterium tuberculosis strains with diﬀerent drug resistance

Andrey Zyubin, Anastasia Lavrova, Eugenie Postnikov, Marine Dogonadze, Elizaveta Demishkevich, Anna Kundalevich, Ilia Samusev

Author Affiliations +

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119003J (2021) https://doi.org/10.1117/12.2602528
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

The Mycobacterium tuberculosis (MbT) drug resistance remains a serious problem for global public health and usually leads to a lethal outcome. Precise and rapid identification of a specific MbT strain is vital for the appointment of antituberculosis therapy. We continue investigation of deactivated MbT strains of the Beijing family by Raman spectroscopy method and focus on Raman spectra analysis for the identification of potential biomarkers for different MbT strains. . We have studied extrapulmonary Beijing strain with XDR resistance. Samples were investigated by Raman spectrometry with He-Ne (λ=633 nm) laser excitation source in the «fingerprint» region. As a result, new spectral features were determined. They describe spectral discrimination between drug-sensitive and drug-resistant strains identified for extra-pulmonary forms of tuberculosis. We suppose that the obtained results can be useful for new diagnostic tools development for the identification of different MbT strains in clinical and research practice.

Conference Presentation

Citation Download Citation

Andrey Zyubin, Anastasia Lavrova, Eugenie Postnikov, Marine Dogonadze, Elizaveta Demishkevich, Anna Kundalevich, and Ilia Samusev "Raman spectroscopy experimental spectrum analysis for identification in Mycobacterium tuberculosis strains with diﬀerent drug resistance", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119003J (9 October 2021); https://doi.org/10.1117/12.2602528

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