In-vivo time-domain diffuse correlation spectroscopy with a superconducting nanowire single-photon detector

L. Colombo; P. Lanka; A. Brodu; N. Noordzij; M. Pagliazzi; V. Parfentyeva; T. Durduran; A. Pifferi

doi:10.1117/12.2614302

9 December 2021 In-vivo time-domain diffuse correlation spectroscopy with a superconducting nanowire single-photon detector

L. Colombo, P. Lanka, A. Brodu, N. Noordzij, M. Pagliazzi, V. Parfentyeva, T. Durduran, A. Pifferi

Author Affiliations +

Proceedings Volume 11920, Diffuse Optical Spectroscopy and Imaging VIII; 1192002 (2021) https://doi.org/10.1117/12.2614302
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

Diffuse correlations spectroscopy (DCS) is a non-invasive optical technique that, studying the speckle intensity fluctuations of light diffused through a biological tissue, measures its microvascular blood flow. Typically, a long coherence length continuous wave source is used, which limits the possibility to resolve the photon path lengths. Recently, time-domain (TD) DCS was proposed, where a pulsed yet coherent light source is used to resolve the speckle fluctuations at different time-of-flights. Due to the constraint of single-speckle detection and time-resolved acquisition, the technique has a limited throughput which limits depth sensitivity. Here, we demonstrate TD DCS with a superconducting nanowire single-photon detector (SNSPD). The SNSPD has a high quantum efficiency and temporal resolution, while maintaining a very low background and no after-pulsing.We report results on phantom and in vivo experiments, which show the potentiality of the proposed detection system for highly accurate TD DCS experiments.

Citation Download Citation

L. Colombo, P. Lanka, A. Brodu, N. Noordzij, M. Pagliazzi, V. Parfentyeva, T. Durduran, and A. Pifferi "In-vivo time-domain diffuse correlation spectroscopy with a superconducting nanowire single-photon detector", Proc. SPIE 11920, Diffuse Optical Spectroscopy and Imaging VIII, 1192002 (9 December 2021); https://doi.org/10.1117/12.2614302

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