Polarization-resolved SHG imaging of lamellar organization in keratoconic human corneas

Clothilde Raoux; Margaux Schmeltz; Marion Bied; Maged Alnawaiseh; Uwe Hansen; Gaël Latour; Marie-Claire Schanne-Klein

doi:10.1117/12.2615711

7 December 2021 Polarization-resolved SHG imaging of lamellar organization in keratoconic human corneas

Clothilde Raoux, Margaux Schmeltz, Marion Bied, Maged Alnawaiseh, Uwe Hansen, Gaël Latour, Marie-Claire Schanne-Klein

Proceedings Volume 11922, Advances in Microscopic Imaging III; 119220L (2021) https://doi.org/10.1117/12.2615711
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

We implement polarization-resolved second harmonic generation microscopy to characterize the orientation distribution of collagen lamellae in human cornea. We evidence a less ordered distribution in keratoconic corneas, in agreement with their deteriorated mechanical behavior.

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Clothilde Raoux, Margaux Schmeltz, Marion Bied, Maged Alnawaiseh, Uwe Hansen, Gaël Latour, and Marie-Claire Schanne-Klein "Polarization-resolved SHG imaging of lamellar organization in keratoconic human corneas", Proc. SPIE 11922, Advances in Microscopic Imaging III, 119220L (7 December 2021); https://doi.org/10.1117/12.2615711

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