Comparison of photoacoustic imaging and histopathological examination in determining the dimensions of 52 human melanomas and nevi ex vivo

Jenny Hult; Aboma Merdasa; Agnes Pekar-Lukacs; Magne Tordengren Stridh; Azin Khodaverdi; John Albinsson; Bodil Gesslein; Ulf Dahlstrand; Linn Engqvist; Yousef Hamid; Douglas Larsson Albér; Bertil Persson; Erlöv Tobias; Sheikh Rafi; Magnus Cinthio; Malin Malmsjö

doi:10.1117/12.2603561

7 March 2022 Comparison of photoacoustic imaging and histopathological examination in determining the dimensions of 52 human melanomas and nevi ex vivo

Jenny Hult, Aboma Merdasa, Agnes Pekar-Lukacs, Magne Tordengren Stridh, Azin Khodaverdi, John Albinsson, Bodil Gesslein, Ulf Dahlstrand, Linn Engqvist, Yousef Hamid, Douglas Larsson Albér, Bertil Persson, Erlöv Tobias, Sheikh Rafi, Magnus Cinthio, Malin Malmsjö

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Proceedings Volume 11934, Photonics in Dermatology and Plastic Surgery 2022; 1193407 (2022) https://doi.org/10.1117/12.2603561
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Reoperations and unnecessary removal of healthy tissue could be reduced if non-invasive imaging techniques were available for presurgical tumor delineation in skin cancer. In this study, 3D multiwavelength photoacoustic imaging was performed ex vivo on 25 melanomas and 27 nevi. The tumors were delineated using spectral unmixing at 59 excitation wavelengths, from 680 nm to 970 nm, accounting for multiple tissue chromophores. The tumor dimensions determined with photoacoustic imaging were strongly correlated with those determined by histopathological examination for both melanomas and nevi.

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Jenny Hult, Aboma Merdasa, Agnes Pekar-Lukacs, Magne Tordengren Stridh, Azin Khodaverdi, John Albinsson, Bodil Gesslein, Ulf Dahlstrand, Linn Engqvist, Yousef Hamid, Douglas Larsson Albér, Bertil Persson, Erlöv Tobias, Sheikh Rafi, Magnus Cinthio, and Malin Malmsjö "Comparison of photoacoustic imaging and histopathological examination in determining the dimensions of 52 human melanomas and nevi ex vivo", Proc. SPIE 11934, Photonics in Dermatology and Plastic Surgery 2022, 1193407 (7 March 2022); https://doi.org/10.1117/12.2603561

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