Early treatment window for predicting breast cancer response to neoadjuvant chemotherapy in the HR+/HER2- subgroup using diffuse optical tomography

Mirella L. Altoe; Alessandro Marone; Hyun K. Kim; Mariella Tejada; Hanina Hibshoosh; Hua Guo; Katherine D. Crew; Melissa K. Accordino; Meghna S. Trivedi; Kevin Kalinsky; Dawn L. Hershman; Andreas H. Hielscher

doi:10.1117/12.2609729

4 March 2022 Early treatment window for predicting breast cancer response to neoadjuvant chemotherapy in the HR+/HER2- subgroup using diffuse optical tomography

Mirella L. Altoe, Alessandro Marone, Hyun K. Kim, Mariella Tejada, Hanina Hibshoosh, Hua Guo, Katherine D. Crew, Melissa K. Accordino, Meghna S. Trivedi, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 11944, Multiscale Imaging and Spectroscopy III; 1194403 (2022) https://doi.org/10.1117/12.2609729
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

This work evaluates changes in features of 3D breast images generated by a so-called dynamic optical tomographic imaging system (DOTBIS) during neoadjuvant chemotherapy (NAC). Images from 23 breast cancer patients were analyzes and correlated with respect to treatment outcome and status of hormone receptors and human epidermal growth factor receptors. Our data shows that the ratio of the mean value of deoxy-hemoglobin (ctHHb_N) at two weeks after the first treatment compared to baseline was statistically significantly lower in patients that achieve a pathologic complete response (pCR) (0.77 ± 0.22) as compared to patients with a non-pCR (1.14 ± 0.24, P < .005). These observations indicate that early changes in DOTBIS images can potentially be used to predict breast cancer response to NAC and may allow a better way to customize therapy to HR+/HER2- patients in order to optimize treatment.

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Citation Download Citation

Mirella L. Altoe, Alessandro Marone, Hyun K. Kim, Mariella Tejada, Hanina Hibshoosh, Hua Guo, Katherine D. Crew, Melissa K. Accordino, Meghna S. Trivedi, Kevin Kalinsky, Dawn L. Hershman, and Andreas H. Hielscher "Early treatment window for predicting breast cancer response to neoadjuvant chemotherapy in the HR+/HER2- subgroup using diffuse optical tomography", Proc. SPIE 11944, Multiscale Imaging and Spectroscopy III, 1194403 (4 March 2022); https://doi.org/10.1117/12.2609729

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