Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals

Eduardo A. Gonzalez; Camryn A. Graham; Muyinatu A. Lediju Bell

doi:10.1117/12.2607825

3 March 2022 Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals

Eduardo A. Gonzalez, Camryn A. Graham, Muyinatu A. Lediju Bell

Author Affiliations +

Proceedings Volume 11960, Photons Plus Ultrasound: Imaging and Sensing 2022; 119600A (2022) https://doi.org/10.1117/12.2607825
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

Our dual wavelength atlas approach to spectral unmixing has the potential to differentiate two chromophores using only two optical wavelengths. This work investigates the optimization of our method by varying six parameters. An iterative process was used to determine the optimal set of parameters by changing each parameter one at a time and finding which value returned the highest combination of sensitivity and specificity. Once the optimal set of parameters were applied, our novel dual-wavelength atlas method resulted in 10% higher balanced accuracy. These results are promising for photoacoustic-guided surgery.

Conference Presentation

Citation Download Citation

Eduardo A. Gonzalez, Camryn A. Graham, and Muyinatu A. Lediju Bell "Optimization of a dual wavelength atlas technique to differentiate methylene blue from hemoglobin in photoacoustic signals", Proc. SPIE 11960, Photons Plus Ultrasound: Imaging and Sensing 2022, 119600A (3 March 2022); https://doi.org/10.1117/12.2607825

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