Effects of photothermal therapy on multicellular tumor spheroids

Trisha I. Valerio; Coline Furrer; Ashley R. Hoover; Wei R. Chen

doi:10.1117/12.2611599

2 March 2022 Effects of photothermal therapy on multicellular tumor spheroids

Trisha I. Valerio, Coline Furrer, Ashley R. Hoover, Wei R. Chen

Proceedings Volume 11961, Biophotonics and Immune Responses XVII; 1196105 (2022) https://doi.org/10.1117/12.2611599
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Pancreatic cancer is one of the deadliest types of cancer due to its ability to metastasize throughout the body. According to the Surveillance, Epidemiology, and End Results Program (SEER), the overall 5-year relative survival rate for pancreatic cancer is 10.8% but once the cancer metastasizes, this survival rate reduces to 3%. Despite recent advances in cancer research, all the current cancer therapies have severe limitations in treating pancreatic cancer. One major challenge in pancreatic cancer research is the lack of an accurate model of the pancreatic tumor and its microenvironment. The common two-dimensional (2D) models are ineffective in mimicking solid tumors. Therefore, there is a need for a better in vitro model to accurately mimic the characteristics of solid pancreatic tumor and to improve assessments for cancer therapies. Here, we generated multicellular tumor spheroids from an aggressive pancreatic cancer cell line, Panc02-H7, and monitored its growth. We also investigated the effects of photothermal therapy through irradiation of a near-infrared laser, which is used to induce immunogenic cell death (ICD) on the tumor spheroids. This three-dimensional (3D) tumor model mimics pancreatic tumors in vitro and this study can generate translatable results and, consequently, guide clinical studies.

Citation Download Citation

Trisha I. Valerio, Coline Furrer, Ashley R. Hoover, and Wei R. Chen "Effects of photothermal therapy on multicellular tumor spheroids", Proc. SPIE 11961, Biophotonics and Immune Responses XVII, 1196105 (2 March 2022); https://doi.org/10.1117/12.2611599

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