NIR spectroscopic immediate effects of irradiation on skin tissue: a comparison study of in vivo and ex vivo

Priya Karthikeyan; Ulriika Honka; Hany Ferdinando; Jesse Lohela; Kalle Inget; Vesa Korhonen; Sakari Karhula; Juha Nikkinen; Teemu Myllylä

doi:10.1117/12.2626362

29 April 2022 NIR spectroscopic immediate effects of irradiation on skin tissue: a comparison study of in vivo and ex vivo

Priya Karthikeyan, Ulriika Honka, Hany Ferdinando, Jesse Lohela, Kalle Inget, Vesa Korhonen, Sakari Karhula, Juha Nikkinen, Teemu Myllylä

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Proceedings Volume 12192, Optical Technologies for Biology and Medicine; 121920Q (2022) https://doi.org/10.1117/12.2626362
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

Radiotherapy is one of the well-established and effective methods for many cancer treatments especially for brain tumors. Despite remarkable advancements, the dose tolerances of normal tissues continue being the main limitation in radiotherapy. Consequently, there is a high unmet medical need to develop predictive biomarkers, and particularly noninvasive real-time methods to establish the radiotherapy effect during the treatment, as well as to optimize radiotherapy dose planning to avoid severe short and long-term toxicities. Optical techniques are well suited for in vivo clinical tissue imaging as they are non-ionizing and can be label-free. In particular, near-infrared (NIR) spectroscopy technology is easy to exploit in online monitoring clinical treatments in demanding clinical environments. In this paper, we study its potential to utilize it in radiotherapy for measuring immediate effects of irradiation on skin tissue. Skin is sensitive to acute side effects of irradiation in radiotherapy and to reduce these unwanted effects is of high interest. We used diffuse reflectance spectroscopy, at spectral range of 650 nm – 1100 nm, and continuously measured human skin in radiotherapy before, during and after irradiation, and compared the response with ex vivo chicken sample measurements. In our results we show that irradiation causes dynamical changes in the detected NIR light when measured in vivo from human skin. These spectral responses could be potentially exploited in development of methods to perceive skin toxicity risks in radiotherapy.

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Priya Karthikeyan, Ulriika Honka, Hany Ferdinando, Jesse Lohela, Kalle Inget, Vesa Korhonen, Sakari Karhula, Juha Nikkinen, and Teemu Myllylä "NIR spectroscopic immediate effects of irradiation on skin tissue: a comparison study of in vivo and ex vivo", Proc. SPIE 12192, Optical Technologies for Biology and Medicine, 121920Q (29 April 2022); https://doi.org/10.1117/12.2626362

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KEYWORDS

Skin

Radiotherapy

In vivo imaging

Tissues

Near infrared

Spectroscopy

Tissue optics

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