Hyperspectral spatial frequency domain imaging for label-free non-contact and wide-field monitoring of tissue optical properties and chromophore concentrations

Yanyu Zhao

doi:10.1117/12.2643356

19 December 2022 Hyperspectral spatial frequency domain imaging for label-free non-contact and wide-field monitoring of tissue optical properties and chromophore concentrations

Yanyu Zhao

Author Affiliations +

Proceedings Volume 12320, Optics in Health Care and Biomedical Optics XII; 123200X (2022) https://doi.org/10.1117/12.2643356
Event: SPIE/COS Photonics Asia, 2022, Online Only

Abstract

The Spatial Frequency Domain Imaging (SFDI) is an emerging label-free imaging technique that can provide quantitative chromophore concentrations in tissue. It has been applied to various biomedical scenarios for the mapping of oxy-hemoglobin, deoxy-hemoglobin, water and lipids, including tumor imaging, inflammation monitoring, brown fat identification, blood lipids monitoring, and others. The key to accurate quantification of all four chromophores with near-infrared light is accurate optical absorption measurement at sufficient number of wavelengths, which has been a major challenge. To address this issue, we develop a hyperspectral SFDI system that is able to measure tissue optical properties in the entire 400 – 1000 nm range. With the proposed system, we’ll demonstrate quantitative mapping of tissue water and lipid content using NIR wavelengths rather than the shortwave infrared, which to the best of our knowledge, is unprecedented in the field of Spatial Frequency Domain Imaging.

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Yanyu Zhao "Hyperspectral spatial frequency domain imaging for label-free non-contact and wide-field monitoring of tissue optical properties and chromophore concentrations", Proc. SPIE 12320, Optics in Health Care and Biomedical Optics XII, 123200X (19 December 2022); https://doi.org/10.1117/12.2643356

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KEYWORDS

Chromophores

Tissue optics

Optical properties

Tissues

Absorption

Cameras

Diffuse reflectance spectroscopy

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